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Millipore Anti-Phospho-Src Family (Tyr416) Antibody, Clone 2n8, Rabbit
Millipore Anti-Phospho-Src Family (Tyr416) Antibody, Clone 2n8, Rabbit
List Price$592.74Your Price$592.74
Millipore This Anti-Phospho-Src Family (Tyr416) Antibody, Clone 2n8 Is Validated For Use In Wb For The Detection Of Phospho-Src Family (Tyr416). - Mill (Additional S&H or Hazmat Fees May Apply)
Anti-phospho-Src family (Tyr416) Antibody, clone 2N8, rabbit monoclonal
Alternate Names
KAT13A
Product Information
Format
Purified
Quality Level
MQ100
Applications
Application
This Anti-phospho-Src family (Tyr416) Antibody, clone 2N8 is validated for use in WB for the detection of phospho-Src family (Tyr416).
Key Applications
Western Blotting
Biological Information
Immunogen
synthetic peptide containing the sequence ...NE[pY]TA, where pY corresponds to phosphotyrosine at position 416 of c-Src.
Clone
2N8
Host
Rabbit
Specificity
phospho-c-Src (Tyr416)
Isotype
IgG
Species Reactivity
Mouse
Vertebrates
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NM_005417
Entrez Gene Summary
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Gene Symbol
SRC
c-src
p60-Src
SRC1
c-SRC
ASV
pp60c-src
Modifications
Phosphorylation
Purification Method
Protein A Purfied
UniProt Number
P12931
UniProt Summary
SIZE: 536 amino acids; 59835 Da SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2. PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity. SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
Molecular Weight
60kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot of endogenous phospho-c-Src immunoprecipitated from NIH/3T3 RIPA lysates with anti-Src, clone GD11 agarose beads (Cat # 16-186)
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
