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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, R, M, Chp | WB, IHC, ICC | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | 06-1005 |
| Description | Anti-TRIC-A Antibody |
| Alternate Names |
|
| Background Information | TRIC-A (trimeric intracellular cation channel type A), also known as Tmem38A, and sometimes NET1, is one of a number of TRIC channel subtypes that are believed to function as a Ca2+ counter-ion channel. TRIC-A is highly expressed in excitable cells and seems to work in coordination with Ca2+ release to balance transient negative potential. TRIC-A is located on the sarcoplasmic reticulum (SR) and is thought to be regulated by trans-membrane voltage. TRIC-A deficiency may lead to an abundance of Ca2+ and cause volatility in Ca2+ movement across the SR membrane. |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Control |
|
| Presentation | Purified rabbit polyclonal in PBS containing 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-TRIC-A Antibody detects level of TRIC-A & has been published & validated for use in WB, IH & IC. |
| Key Applications |
|
| Application Notes | Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Wilkie, g.S., et Al. (2011). Mol Cell Proteomics. 10(1):M110.003129-1). Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC. (Wilkie, g.S., et Al. (2011). Mol Cell Proteomics. 10(1):M110.003129-1). |
| Biological Information | |
|---|---|
| Immunogen | KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human TRIC-A. |
| Epitope | Cytoplasmic domain |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Specificity | This antibody recognizes the cytoplasmic domain of TRIC-A. |
| Species Reactivity |
|
| Species Reactivity Note | Demonstrated to react with Human, Rat, and Mouse. Predicted to react with Chimpanzee based on 100% sequence homology. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
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| Gene Symbol |
|
| Purification Method | Affinity Purfied |
| UniProt Number |
|
| UniProt Summary | FUNCTION: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). SUBUNIT STRUCTURE: Homotrimer (By similarity). SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane (By similarity). DOMAIN: The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, SO that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore. SEQUENCE SIMILARITIES: Belongs to the TMEM38 family. |
| Molecular Weight | ~33 kDa observed |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blot in human fetal skeletal muscle tissue lysate. Western Blot Analysis: 1 µg/mL of this antibody detected TRIC-A on 10 µg of human fetal skeletal muscle tissue lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |