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Millipore Use Anti-Septin-2 Antibody (Rabbit Polyclonal Antibody) Validated In Wb, If To Detect Septin-2 Also Known As Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 5, Septin 2. - Mill (Additional S&H or Hazmat Fees May Apply)
Septin-2 belongs to the septin family of GTPases. Originally characterized as regulators of cytokinesis, septins were later implicated in other cellular processes. Recent studies show that septins have a broader role in microtubule-dependent processes, such as karyokinesis, exocytosis, and maintenance of cell shape. Many members of the septin family have been shown to colocalize or interact with the microtubule cytoskeleton, suggesting that these might be general properties of septins. Septin-2 is expressed in the brain and may be associated with Alzheimers disease.
Product Information
Format
Serum
Control
Hek293 cell lysate
Presentation
Unpurified rabbit polyclonal with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Use Anti-Septin-2 Antibody (Rabbit Polyclonal Antibody) validated in WB, IF to detect Septin-2 also known as Neural precursor cell expressed developmentally down-regulated protein 5, septin 2.
Key Applications
Western Blotting
Immunofluorescence
Application Notes
Immunofluorescence: Reported by external laboratory using representative lot.
Biological Information
Immunogen
His-tagged recombinant protein corresponding to human Septin-2.
Epitope
Unknown
Host
Rabbit
Specificity
This antibody recognizes Septin-2.
Species Reactivity
Human
Mouse
Rat
Species Reactivity Note
Proven to react with human, mouse, and rat.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_004395.1
Gene Symbol
SEPT2
DIFF6
NEDD-5
NEDD5
Pnutl3
hNedd5
Purification Method
Unpurified
UniProt Number
Q15019
UniProt Summary
FUNCTION: Required for normal progress through mitosis. Involved in cytokinesis.
SUBUNIT STRUCTURE: Monomer, and homodimer. Nucleotide binding promotes dimerization. Heterohexamer composed of two heterotrimers containing one copy each of SEPT2, SEPT6 and SEPT7. The asymmetrical heterotrimers associate head-to-head to form a hexameric unit that assembles into filaments.
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm › cytoskeleton › spindle. Note: Accumulates near the contractile ring from anaphase through telophase, and finally condenses into the midbody. In interphase and postmitotic cells, localized to fibrous or granular structures, depending on the growth state of the cell By similarity.
SEQUENCE SIMLARITIES: Belongs to the septin family.
Molecular Weight
41 kDa
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in Hek293 cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Septin-2 on 10 µg of Hek293 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
