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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | IP, WB, IHC | Rb | Serum | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | 07-394 |
| Brand Family | Upstate |
| Trade Name |
|
| Description | Anti-MAGE-D1/NRAGE Antibody |
| Product Information | |
|---|---|
| Format | Serum |
| Presentation | 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, before the addition of glycerol to 30% |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-MAGE-D1/NRAGE Antibody is an antibody against MAGE-D1/NRAGE for use in IP, WB, IH. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | GST fusion protein corresponding to residues 53-295 of rat MAGE-D1/NRAGE |
| Host | Rabbit |
| Specificity | NRAGE/MAGE-D1 |
| Isotype | IgG |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. |
| Gene Symbol |
|
| Purification Method | Antiserum |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: Q9Y5V3 # Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation. SIZE: 778 amino acids; 86161 Da SUBUNIT: Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A (By similarity). Interacts with the p75 neurotrophin receptor. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF (By similarity). TISSUE SPECIFICITY: Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed. SIMILARITY: SwissProt: Q9Y5V3 ## Contains 1 MAGE domain. |
| Molecular Weight | 90-96 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | routinely evaluated by immunoblot in RIPA lysates from PC12 cells |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | 2 years at -20°C |
| Packaging Information | |
|---|---|
| Material Size | 200 µL |