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Millipore Anti-Cenp-B Antibody Is A Rabbit Polyclonal Antibody For Detection Of Cenp-B Also Known As Centromere Autoantigen B & Has Been Tested In Wb. - Mill (Additional S&H or Hazmat Fees May Apply)
Anti-CENP-B Antibody is a Rabbit Polyclonal Antibody for detection of CENP-B also known as Centromere autoantigen B & has been tested in WB.
Key Applications
Western Blotting
Biological Information
Immunogen
Beta galactosidase fusion protein of human CENP-B.
Host
Rabbit
Specificity
Beta galactosidase fusion protein of human CENP-B.
Isotype
IgG
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_001810.5
Entrez Gene Summary
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
Gene Symbol
CENPB
CENP-B
Purification Method
Protein A Purfied
UniProt Number
P07199
UniProt Summary
FUNCTION: SwissProt: P07199 # Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes. SIZE: 599 amino acids; 65171 Da SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: SwissProt: P07199 ## Contains 1 HTH CENPB-type DNA-binding domain. & Contains 1 HTH psq-type DNA-binding domain.
Molecular Weight
80kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
