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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | ELISA, FC, RIA, WB, IH(P) | Rb | Serum | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB8902 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Glutathione-S-Transferase-pi Antibody, mammalian form |
| Alternate Names |
|
| Product Information | |
|---|---|
| Format | Serum |
| Presentation | Liquid rabbit serum. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Glutathione-S-Transferase-pi Antibody, mammalian form is an antibody against Glutathione-S-Transferase-pi for use in ELISA, FC, RIA, WB, IH(P). |
| Key Applications |
|
| Application Notes | Histochemistry of paraffin sections and cryosections ELISA RIA Western Blot Flow cytometry Optimal working dilutions must be determined by end user. |
| Biological Information | |
|---|---|
| Immunogen | Recombinant Glutathione-S-Transferase purified from E. coli protein extracts |
| Epitope | mammalian form |
| Host | Rabbit |
| Specificity | GST-pi belongs to a family of isoenzymes involved in the detoxification of xenobiotics, including carcinogens. GST-pi exists in various tumor tissues and neoplastic lesions. GST-pi is described as a possible histochemical and serological marker for various human neoplasms. Antibody AB8902 has been demonstrated to have reactivity with GST-pi by western blot and RIA. Cross-reactivities with other GST isoenzymes (μ or alpha) and GS-peroxidase were less than 0.1%. No detectable cross-reactivity with other tissue and serum proteins is evident. |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. |
| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P09211 # Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. SIZE: 210 amino acids; 23356 Da SUBUNIT: Homodimer. SIMILARITY: SwissProt: P09211 ## Belongs to the GST superfamily. Pi family. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain frozen at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 50 µL |