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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, H, M, R | WB | Sh | Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB9014 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Chx10 Antibody, CT |
| Alternate Names |
|
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | Purified immunoglobulin. Liquid in PBS containing 0.08% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-Chx10 Antibody, C-terminus is validated for use in WB for the detection of Chx10. |
| Key Applications |
|
| Application Notes | Immunoblotting: 0.5-1.0 μg/mL. Reacts with the 46 kD protein in rat and mouse retinal tissue lysate. Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | Recombinant human Chx10 protein, C-terminal. |
| Epitope | C-terminus |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Sheep |
| Specificity | Chx10 |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P58304 # Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity). SIZE: 361 amino acids; 39411 Da SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Abundantly expressed in retinal neuroblasts during eye development and in the inner nuclear layer of the adult retina. Within this layer, expression is stronger in the outer margin where bipolar cells predominate. DISEASE: SwissProt: P58304 # Defects in VSX2 are the cause of microphthalmia with cataracts and iris abnormalities [MIM:610092]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. It is a cause of congenital blindness. & Defects in VSX2 are the cause of isolated microphthalmia with coloboma 3 (MCOPCB3) [MIM:610092]; also known as isolated colobomatous microphthalmia 3. & Defects in VSX2 are the cause of isolated microphthalmia 2 (MCOP2) [MIM:610093]; also known as clinical anophthalmia. SIMILARITY: SwissProt: P58304 ## Belongs to the paired homeobox family. & Contains 1 CVC domain. & Contains 1 homeobox DNA-binding domain. & Contains 1 OAR domain. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 250 µg |