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Millipore Anti-Caps-2 Detects Levels Of Caps-2 Proteins & Has Been Published & Validated For Use In Wb & Ihc. - Mill (Additional S&H or Hazmat Fees May Apply)
CAPS-2 and the related protein CAPS-1 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. Like CAPS-1, numerous isoforms of CAPS-2 are known to exist. These isoforms show distinct expression patterns in the brain. For example, CAPS2b showed high expression in the developing cerebellum. Furthermore, one version of CAPS-2 mRNA that lacks exon 3 is detected in some autistic patients, suggesting that the differential expression pattern of CAPS-2 is involved in neuronal development.
Product Information
Format
Affinity Purified
Control
Mouse brain tissue lysate
Presentation
Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-CAPS-2 detects levels of CAPS-2 proteins & has been published & validated for use in WB & IHC.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Western Blot Analysis: 1 µg/mL from a representative lot detected CAPS-2 in 10 µg/mL of human brain tissue lysate.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected CAPS-2 in rat cerebellum tissue.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human CAPS-2.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
This antibody is predicted to be specific to CAPS-2 and not recognize CAPS-1.
Species Reactivity
Human
Mouse
Rat
Antibody Type
Polyclonal Antibody
Gene Symbol
CADPS2
CAPS2
Purification Method
Antigen Affinity Purified
UniProt Number
Q86UW7
Molecular Weight
~160 kDa observed. Uncharacterized bands may appear at ~40 kDa, ~50 kDa, and ~210 kDa in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected CAPS-2 in 10 µg/mL of mouse brain tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
