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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M | WB, ICC, IHC, FC | R | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MAB4416 |
| Description | Anti-Plet-1 (Placenta-expressed transcript 1 protein) Antibody, clone 1D4 |
| Alternate Names |
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| Background Information | Placenta-expressed transcript-1 (Plet-1) is a recently identified protein that as of yet has no known function and is not associated with any one family of proteins. Its observation has been restricted to developing mesonephros and pharyngeal endoderm. Observation in adult tissue is more widely expressed, having been found in several locations such as mammary, pancreas and prostate epithelia. Its location in the pancreas is notable as the pancreas is a well known reserve for stem cells and progenitor cells. Within the pancreas, Plet-1 has been shown to be localized in the major duct epithelium, and as such will serve as an excellent marker for epithelial progenitor cells and stem cells, and as a useful implement for observing the genetics of linear relationships and the operation of molecular mechanisms for homeostasis, development and wound healing in organ and tissue systems. Recently, Plet-1 has been identified as a specific marker of early thymic epithelial progenitor cells. In the postgastrulation embryo, Plet-1 expression is highly restricted to the developing pharyngeal endoderm and mesonephros. This antibody recognizes the same protein as MTS20 and MTS24. |
| Product Information | |
|---|---|
| Format | Purified |
| Control |
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| Presentation | Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-Plet-1 (Placenta-expressed transcript 1 protein) Antibody, clone 1D4 is validated for use in WB, IC, IH, FC for the detection of Plet-1 (Placenta-expressed transcript 1 protein). |
| Key Applications |
|
| Application Notes | Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC (Depreter, M.G.L., et al., 2008). Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Depreter, M.G.L., et al., 2008). Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC (Depreter, M.G.L., et al., 2008). |
| Biological Information | |
|---|---|
| Immunogen | Full length recombinant protein corresponding to Plet-1. |
| Epitope | Unknown |
| Clone | 1D4 |
| Host | Rat |
| Specificity | This antibody recognizes Plet-1. |
| Isotype | IgG2aκ |
| Species Reactivity |
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| Species Reactivity Note | Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology. |
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
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| Gene Symbol |
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| Purification Method | Protein G Purified |
| UniProt Number |
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| UniProt Summary | FUNCTION: May participate in the wound response during the healing process, and promote wound repair. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential. |
| Molecular Weight | ~ 23 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blot in human placenta cell lysate. Western Blot Analysis: A 1:2,500 dilution of this antibody detected Plet-1 in 10 µg of human placenta cell lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |