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Millipore This Anti-26s Proteasome Regulatory Subunit Rpn11, Clone 7c7.1 Antibody Is Validated For Use In Western Blotting And Immunohistochemistry (Paraffin) For The Detection Of - Mill (Additional S&H or Hazmat Fees May Apply)
26S proteasome non-ATPase regulatory subunit 14 is also known as 26S proteasome regulatory subunit RPN11 or 26S proteasome-associated PAD1 homolog 1. This protein is expressed from the PSMD14 gene and is the metalloprotease component of the 26S proteasome that specifically cleaves Lys-63-linked polyubiquitin chains. 26S proteasome non-ATPase regulatory subunit 14 has a role in the response to double-strand breaks (DSBs) by regulating non-homologous end joining (NHEJ) via cleaving Lys-63-linked polyubiquitin, retaining JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. 26S proteasome non-ATPase regulatory subunit 14 is also involved in homologous recombination repair by promoting RAD51 loading. 26S proteasome non-ATPase regulatory subunit 14 is widely expressed, but found in the highest levels in heart and skeletal muscle.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG2bκ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-26S proteasome regulatory subunit RPN11, clone 7C7.1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of 26S proteasome regulatory subunit RPN11.
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected 26S proteasome regulatory subunit RPN11 in human cardiac myocytes and rat skelatal muscle myocytes.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to 26S proteasome regulatory subunit RPN11.
Evaluated by Western Blotting in HT-1080 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected 26S proteasome regulatory subunit RPN1 in 10 µg of HT-1080 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
