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Millipore This Anti-Trem-1, Clone 2(1a2) Antibody Is Validated For Use In Flow Cytometry For The Detection Of Trem-1. - Mill (Additional S&H or Hazmat Fees May Apply)
Triggering receptor expressed on myeloid cells 1 (TREM-1) is a membrane bound protein and secreted protein that is expressed by most cells in many tissues including liver, lung, spleen, lymph node, heart, and even spinal cord in response to bacterial and fungal infections. TREM-1 stimulates neutrophil and monocyte mediated inflammatory responses. TREM-1 also triggers pro-inflammatory chemokines and cytokines as well as increases surface expression of cell activation markers like CD11, thus TREM-1 acts as an amplifier of inflammatory responses in response to these pathogens. TREM-1 similarly is a potent LPS response factor and its expression is upregulated by LPS released by bacterial and fungal infections, and thus TREM-1 is a critical mediator of septic shock caused by such infections.
Product Information
Format
ATT-550
Presentation
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-TREM-1, clone 2(1a2) Antibody is validated for use in Flow Cytometry for the detection of TREM-1.
Key Applications
Flow Cytometry
Biological Information
Immunogen
Recombinant protein corresponding to human TREM-1.
Clone
2(1a2)
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG2bκ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_001229518
Gene Symbol
TREM1
Purification Method
Protein G Purified
UniProt Number
Q9NP99
Molecular Weight
26 kDa calculated
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in human peripheral blood mononuclear.
Flow Cytometry Analysis: 0.25 µg of this antibody detected TREM-1 in human peripheral blood mononuclear cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
