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Millipore This Anti-S100a9/Mrp14 Antibody, Clone 17 Is Validated For Use In Western Blotting And Flow Cytometry For The Detection Of S100a9/Mrp14. - Mill (Additional S&H or Hazmat Fees May Apply)
S100A8, also known as Protein S100-A8, Calgranulin-A, Calprotectin L1L subunit, Cystic fibrosis antigen (CFAG), Leukocyte L1 complex light chain, Migration inhibitory factor related protein 8 (MRP-14), p8, S100 calcium binding protein A8, or Urinary stone protein band A, and encoded by the gene S100A8/CAGA/CFAG/MRP14, is an important protein that binds both zinc and calcium and plays an important role in the regulation of inflammatory processes and immune response. Found in complex with its partner S100A9, S100A8 facilitates chemotaxis, fatty acid trafficking, cytoskeleton reorganization, and NAPDPH oxidase activation and other intracellular activities, as well as a host of extracellular induced activities such as extracellular proinflammatory, antimicrobial, oxidant scavenging, and apoptotic activities . Additionally S100A8 can act as a potent autoimmunity amplifier and appears to augment various cancers and their spread when over expressed. S100A8 is widely expressed and used as biomarker in patients with inflammatory diseases and as a cancer marker in multiple forms of cancer.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-S100A9/MRP14 Antibody, clone 17 is validated for use in Western Blotting and Flow Cytometry for the detection of S100A9/MRP14.
Key Applications
Western Blotting
Flow Cytometry
Application Notes
Flow Cytometry Analysis: 0.5 µg of this antibody from a representative lot detected S100A9/MRP14 in 1X10E6 peripheral blood mononuclear cells.
Biological Information
Immunogen
Recombinant protein corresponding to human S100A9/MRP14.
Clone
17
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_002956
Gene Symbol
S100A9
CAGB
CFAG
MRP14
Purification Method
Protein G Purified
UniProt Number
P06702
Molecular Weight
~13 kDa observed. Uncharacterized bands may be observed in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human spleen tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected S100A9/MRP14 in 10 µg of human spleen tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
