Roche Diagnostics Corporation Anti-Chromogranin A (Lk2h10) Pab

Roche Diagnostics Corporation anti-chromogranin a (lk2h10) pab; this antibody is intended for in vitro diagnostic use. ventana medical systems, inc. (ventana) anti-chromogranin a (lk2h1) primary antibody contains a mouse monoclonal antibody (igg1) directed against a protein found in the secretory granules of most endocrine cells.1 the chromogranin a protein is widely expressed in neuronal tissues and in the secretory granules of human endocrine cells. chromogranin a is also expressed by adrenal (medulla), parathyroid, anterior pituitary cells, islet cells of the pancreas, gastrointestinal cells, bronchial endocrine cells, and thyroid c-cells. chromogranin a is expressed in tumors of neuroendocrine origin, including pheochromocytomas, pituitary adenomas, islet cell tumors, medullary thyroid carcinomas, carcinoids and merkel cell tumors. this reagent may be used to aid in the identification of cells of normal or neoplastic neuroendocrine lineage. the antibody is intended for qualitative staining in sections of formalin fixed, paraffin embedded tissue on a ventana automated slide stainer. anti-chromogranin a (lk2h1) specifically binds to the chromogranin a protein located in the secretory granules of normal and neoplastic neuroendocrine cells. unexpected antigen expression or loss of expression may occur, especially in neoplasms. occasionally stromal elements surrounding heavily stained tissue and/or cells will show immunoreactivity. the clinical interpretation of any staining, or the absence of staining, must be complemented by morphological studies and evaluation of proper controls. evaluation must be made by a qualified pathologist within the context of the patients clinical history and other diagnostic tests. caution: u.s. federal law restricts this device to sale by or on the order of a physician. - ROCHMSD (Additional S&H or Hazmat Fees May Apply)