Roche Diagnostics Corporation Cell Marque, Bcl-6

Roche Diagnostics Corporation cell marque, bcl-6; anti-bcl-6 is a transcriptional regulator gene which codes for a 76-amino-acid nuclear zinc finger protein. antibodies to this protein stain the germinal center cells in lymphoid follicles, the follicular cells and interfollicular cells in follicular lymphoma, diffuse large b-cell lymphomas, and burkitts lymphoma, and the majority of the reed-sternberg cells in nodular lymphocyte predominant hodgkins disease. in contrast, anti-bcl-6 rarely stains mantle cell lymphoma and malt lymphoma. anti-bcl-6 expression is seen in approximately 45% of cd3+ anaplastic large cell lymphomas but is consistently absent in other peripheral t-cell lymphomas. bcl-6 is protected by u.s. patents 6, 174, 997 and 6, 783, 94 (cancer genetics, inc.) - ROCHMSD (Additional S&H or Hazmat Fees May Apply)