Roche Diagnostics Corporation Oct-2 (Mrq-2) Pab, Cell Marque

Roche Diagnostics Corporation oct-2 (mrq-2); oct-2 is a transcription factor of the pou homeo-domain family that binds to the ig gene octamer sites, regulating b-cell-specific genes. these are involved in proliferation and differentiation and despite the scarce evidence for oct-2 expression in t cells, it has been shown that this factor participates in transcriptional regulation during t-cell activation. oct-2 activity is dependent on phosphorylation and alternatitive splicing, although it seems that the level of its expression can be used as a marker of b-cell lineage and differentiation. the following show high levels of oct-2 expression: germinal center b-cells, mantle b-cells, monocytoid b-cells, and plasma cells. various lymphomas are also positive for this marker including the following: b-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, burkitt lymphoma, diffuse large cell lymphoma, diffuse large b-cell lymphoma, t-cell rich b-cell lymphoma, nodular lymphocyte predominant hodgkin lymphoma, classic hodgkin lymphoma. - ROCHMSD (Additional S&H or Hazmat Fees May Apply)