Cell Signaling Ddx41 (D3f1z) Rabbit mAb

Name: Cell Signaling Ddx41 (D3f1z) Rabbit mAb
SKU: CSIG-15076S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Ddx41 (D3f1z) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-15076S

MFG.PART: 15076S

UNSPSC: 41116124

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	75
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	DDX41 (D3F1Z) Rabbit mAb recognizes endogenous levels of total DDX41 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala98 of human DDX41 protein.
Background	The DEAD box helicase DDX41 is an antiviral protein that senses cytosolic DNA and activates the signaling adaptor STING to induce type I interferon production (1). The recognition of bacterial dinucleotides by DDX41 also leads to STING-dependent type 1 interferon production (2). Research studies demonstrate that knockdown of DDX41 attenuates poly(dA:dT)-induced IFN-β production and cyclic GMP-AMP synthase (cGAS, MB21D1) induction (3). The DDX41 protein is thought to be an initial constitutively expressed DNA sensor that activates type I interferon production and leads to cGAS amplification of type I interferon production (3). DDX41 is negatively regulated by the E3 ligase TRIM21 (4). Both germline and somatic mutations in the corresponding DDX41 gene are associated with myeloid neoplasms (5,6).

Specifications