Cell Signaling Zap-70 (136f12) Rabbit mAb (Pe Conjugate)

Name: Cell Signaling Zap-70 (136f12) Rabbit mAb (Pe Conjugate)
SKU: CSIG-93339S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Zap-70 (136f12) Rabbit mAb (Pe Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-93339S

MFG.PART: 93339S

UNSPSC: 41116124

Manufacturer: Cell Signaling

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze.
Specificity/Sensitivity	Zap-70 (136F12) Rabbit mAb (PE Conjugate) recognizes endogenous levels of total Zap-70 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human Zap-70 protein.
Background	The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement (1). Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck (2-6). Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia (7,8).

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