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This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gene Symbol
SGK3
CISK
DKFZp781N0293
SGK2
SGKL
Protein Target
SGK3
Target Sub-Family
AGC
UniProt Number
Q96BR1
UniProt Summary
FUNCTION: SwissProt: Q96BR1 # Involved in the activation of potassium channels. Mediates cell IL-3-dependent survival signals (By similarity). SIZE: 496 amino acids; 57108 Da SUBCELLULAR LOCATION: Cytoplasmic vesicle (By similarity). Early endosome (By similarity). Note=Localized in vesicle-like structures and in the early endosome (By similarity). TISSUE SPECIFICITY: Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. SIMILARITY: SwissProt: Q96BR1 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain. & Contains 1 PX (phox homology) domain.
Product Usage Statements
Quality Assurance
Routinely evaluated by phosphorylation using SGK3, active (Catalog # 14-647).
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
