Sigma-Aldrich Sodium Dihydr. Phosph. Mon

Grade

ACS reagent

Quality Level

300

Agency

reag. pH. Eur.

Product Line

EMSURE^®

Assay

99.0-102.0% (alkalimetric)

Form

crystals

Potency

>2000 mg/kg LD₅₀, oral (Rat)
>7940 mg/kg LD₅₀, skin (Rabbit)

Impurities

≤0.01% Insoluble matter

pH

4.1-4.5 (25 °C, 50 g/L in H₂O)

Solubility

850 g/L

Related Categories

Phosphates

Salts

Application

• Development of a multiparticulate drug delivery system for in situ amorphisation.: This study explores the use of sodium dihydrogen phosphate monohydrate in developing a multiparticulate drug delivery system. The research highlights the compound′s role in achieving in situ amorphisation, enhancing drug solubility and bioavailability (Holm TP et Al., 2022).


• Metabolomic characterization of rhubarb species by capillary electrophoresis and ultra-high-pressure liquid chromatography.: Sodium dihydrogen phosphate monohydrate is utilized in the buffer system for capillary electrophoresis and UHPLC, aiding in the metabolomic analysis of rhubarb species. This research underscores its importance in improving separation efficiency and resolution in analytical methods (Tseng YJ et Al., 2013).

Linkage

Replaces: SX0709; SX0709-5; SX0710; SX0710-1; SX0710-3; SX0710-5; SX0710-20

Analysis Note

Assay (alkalimetric): 99.0 - 102.0 %
Insoluble matter: ≤ 0.01 %
pH-value (5 %; water, 25 °C): 4.1 - 4.5
UV absorption (280 nm; 1 mol/L; 1 cm; water): ≤ 0.05
Chloride (Cl): ≤ 0.0005 %
Sulfate (SO₄): ≤ 0.003 %
Total nitrogen (N): ≤ 0.001 %
Heavy metals (ACS): ≤ 0.0005 %
Ca (Calcium): ≤ 0.005 %
Fe (Iron): ≤ 0.0005 %
K (Potassium): ≤ 0.005 %
Corresponds to ACS,Reag. pH EurEMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany