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Sigma-Aldrich Antipain Activity: ≫500
List Price $603.20 Your Price $603.20
Sigma-Aldrich Antipain Activity: ≫50000 Units/mg - SIAL (Additional S&H Or Hazmat Fees May Apply)
NETA PART: SIAL-10791-25MG
MFG.PART: 10791-25MG
UNSPSC: 12352202
Manufacturer: Sigma-Aldrich
Quality Level
100
specific activity
>50000 U/mg
mode of action
enzyme | inhibits
storage temp.
−20°C
SMILES string
[H]C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C(C)C
InChI
1S/C27H44N10O6/c1-16(2)21(23(40)34-18(15-38)10-6-12-32-25(28)29)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17/h3-5,8-9,15-16,18-21H,6-7,10-14H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)/t18?,19-,20-,21-/m0/s1
InChI key
SDNYTAYICBFYFH-KTYMLHDXSA-N
General description
Chemical structure: peptide
Biochem/physiol Actions
Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.[1]
Inhibits serine/cysteine proteases and some trypsin-like proteases. Compare activity to that of leupeptin. Used to evaluate the role of proteases in cell transformations. Used to help identify new proteases.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Unit Definition
1 U corresponds to the amount of inhibitor which reduces the trypsin activity by 1 BAEE-U. (1 BAEE-U is the amount of enzyme which increases the absorbance at 253 nm by 0.001 per minute at pH 7.6 and 25°C; BAEE, Cat. No. 12880, as substrate)
Other Notes
Protease inhibitor[2]
wgk_germany
WGK 2
PPE
Eyeshields, Gloves, type N95 (US)
| SKU | SIAL-10791-25MG |
|---|---|
| Supplier Part Number | 10791-25MG |
| UM | EA |
| UNSPSC | 12352202 |
| Manufacturer | Sigma-Aldrich |
| Temperature | -20C |
| Refrigerated-Frozen | Y |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 10.000000 |
| Lead Time | 9 |
| Hazardous | Y |
| CAS Number | 37691-11-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |