Revvity HTRF Human Total BRD2 Detection Kit

Revvity BRD2 belongs to the bromodomain (BRD) Family II (BET). Like the other BRD family proteins, it binds to acetylated lysine and acts as a reader of the lysine acetylation state of proteins such as histones. It is a transcriptional regulator involved in many cell processes (embryogenesis, cycle regulation, development) through the E2F-RB pathway. BRD2 dysregulation is has been widely linked to many cancers, as it regulates the transcription of several oncogenes such as c-MYC ad Bcl-2. Thus, inhibition of the BRD2 function has become part of the strategy for cancer treatments. More recently, targeting BET family protein degradation, including BRD2 via PROTAC molecules, has emerged as a novel and promising therapeutic approach. - PEGSK (Additional S&H or Hazmat Fees May Apply)