Revvity HTRF Human Total BRD3 Detection Kit

Revvity BRD3 belongs to the bromodomain (BRD) Family II (BET). Like the other BRD family proteins, it binds to acetylated lysine and acts as a reader of the lysine acetylation state of proteins such as histones. It is a transcriptional regulator involved in many cell processes ( embryogenesis, cycle regulation, development) through the E2F-RB pathway. BRD3 interacts with the GATA transcription factor for its chromatin occupancy and the regulation of several oncogenes, such as c-MYC. Thus, inhibition of BRD3 function has become part of the strategy for cancer treatments. More recently, targeting BET family protein degradation, including BRD3 via PROTAC molecules, has emerged as a novel and promising therapeutic approach. - PEGSK (Additional S&H or Hazmat Fees May Apply)