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Cell Signaling Foxc2 (D4d4) Rabbit mAb
List Price $354.51 Your Price $354.51
Cell Signaling Foxc2 (D4d4) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSIG-12974S
MFG.PART: 12974S
UNSPSC: 12352300
Manufacturer: Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 60 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | FoxC2 (D4D4) Rabbit mAb recognizes endogenous levels of total FoxC2 protein. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu278 of human FoxC2 protein. |
| Background | Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors defined by the presence of a winged helix DNA binding domain called a Forkhead box (1). In humans, there are over 40 known Fox protein family members, divided into 19 subfamilies, which have evolved to regulate gene transcription in diverse and highly specialized biological contexts throughout development (2). Mutations that disrupt the expression of Fox gene family members have consequently been implicated in a broad array of human disorders, including immunological dysfunction, infertility, speech/language disorders, and cancer (3,4).The expression of FoxC2 and several other Fox transcription factors are regulated during adipogenesis, suggesting their involvement in adipocyte differentiation (5). A transgenic mouse model exhibiting over expression of FoxC2 in white adipose tissue (WAT) and brown adipose tissue (BAT) showed a reduction of the intra-abdominal WAT depot (6). The BAT-specific gene Ucp1 is upregulated in the intra-abdominal WAT depot of these transgenic mice, resulting in histological features similar to those seen in BAT. This evidence suggests that FoxC2 can play a protective role against obesity and diet-induced insulin resistance (6). |
| SKU | CSIG-12974S |
|---|---|
| Supplier Part Number | 12974S |
| UM | EA |
| UNSPSC | 12352300 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |