Cell Signaling Pgd Antibody

Name: Cell Signaling Pgd Antibody
SKU: CSIG-13389S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Pgd Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-13389S

MFG.PART: 13389S

UNSPSC: 12352300

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	49
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	PGD Antibody recognizes endogenous levels of total PGD protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala300 of human PGD protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	6-phosphogluconate dehydrogenase (PGD or 6PGD) catalyzes the conversion of 6-phosphogluconate and NADP+ to ribulose 5-phosphate and NADPH in the pentose phosphate pathway (1). Research studies show that knockdown of PGD results in the induction of senescence and inhibition of growth of lung cancer cells (2). Additional research suggests that PGD influences the migration of some cancer cells by regulating c-Met phosphorylation state (3). Furthermore, it was shown that the glycolytic enzyme PGAM1 substrate (3-phosphoglycerate) regulates the pentose phosphate pathway by deactivating PGD/6PGD (4).

Specifications