Cell Signaling Citrate Synthase (D7v8b) Rabbit mAb

Name: Cell Signaling Citrate Synthase (D7v8b) Rabbit mAb
SKU: CSIG-14309S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Citrate Synthase (D7v8b) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-14309S

MFG.PART: 14309S

UNSPSC: 12352300

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Hm Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	45
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunofluorescence (Immunocytochemistry): 1:50 - 1:100}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Citrate Synthase (D7V8B) Rabbit mAb recognizes endogenous levels of total citrate synthase protein.
Species Reactivity	Human, Mouse, Rat, Hamster, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human citrate synthase protein.
Background	Citrate synthase (CS) is a mitochondrial enzyme that catalyzes the first and rate-limiting reaction of the citric acid cycle (1,2). The enzyme is responsible for the conversion of oxaloacetate and acetyl-CoA to citrate and CoA (1,2). Research studies show that CS knockdown HeLa cells are more malignant than vector-transfected cells from an in vivo xenograft model, which suggests a direct link between the Warburg Effect and tumor growth (2). Intervertebral disc degeneration, a growing health problem, has been linked to changes in citrate synthase activity (3).

Specifications