Cell Signaling Gmps Antibody

Name: Cell Signaling Gmps Antibody
SKU: CSIG-14602S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Gmps Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-14602S

MFG.PART: 14602S

UNSPSC: 12352300

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	76
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	GMPS Antibody recognizes endogenous levels of total GMPS protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human GMPS protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Guanine monophosphate synthase (GMPS) catalyzes the conversion of xanthosine 5’-monophosphate (XMP) into GMP during the final step of de novo guanine nucleotide synthesis. In addition to comprising the building blocks for DNA and RNA, guanine nucleotides also provide GTP for many signaling pathways that are important for multiple cellular processes (1). Chromosomal translocations involving MLL and GMPS is reported in some patients diagnosed with acute myeloid leukemia (2). Research studies indicate that genotoxic stress or nucleotide deprivation prompts translocation of GMPS to the nucleus where it complexes with USP7 and p53 to promote p53 stabilization (3). Additional studies show that the nuclear GMPS-USP7 protein complex deubiquitinates histone H2B in Drosophila (4).

Specifications