Sigma-Aldrich SMC Human Interleukin 17A (IL-17A) (V2) Immunoassay Kit

Interleukin-17A (IL-17A) is the founding member of a group of cytokines called the IL-17 family. There are several members of the IL-17 family, from IL-17A to IL-17F (IL-17E is also called IL-45). IL-17A is involved in mediating proinflammatory responses by inducing the production of many other cytokines, chemokines, and prostaglandins from many cell types. The increased expression of chemokines attracts other cells, including neutrophils. IL-17A has many physiological functions, such as airway remodeling. As a result of these roles, the IL-17 family has been linked to many immune/autoimmune related diseases, including rheumatoid arthritis (RA), asthma, allergic responses, lupus, allograft rejection and anti-tumor immunity.

The SMC^® IL-17A (V2) Immunoassay Kit contains all reagents required to perform the assay. This assay takes advantage of a standard immunoassay workflow configured in a standard plate format. Assay protocols are similar to existing sandwich ELISA methods with two key differences: 1) Elution buffer disrupts the sandwich, separating the labeled detection antibody for quantification. 2) The SMC^® immunoassay system detects analytes using Single Molecule Counting (SMC^®) technology.

Research Category
Inflammation & Immunology

Research Sub Category
Cytokines & Cytokine Receptors

The sensitivity of Single Molecule Counting (SMC^®) technology gives the SMC^® Human IL-17A (V2) Immunoassay Kit unparalleled performance in the quantification of IL-17A in human EDTA plasma and serum.

Used to detect/quantify:IL-17A

IL-17A Coated Beads (V2)
Standard Diluent
IL-17A Detection Antibody (V2)
Assay Buffer
IL-17A Standard
10X Wash Buffer
Elution Buffer B
Buffer D
SMC^® IL-17A (V2) Immunoassay Kit Instructions

Low-end CV% Range: 1-13%|Low-end CV% Average: 6%

SMC is a registered trademark of Singulex

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial