Sigma-Aldrich Paraffin Pastilles Solidif

Quality Level

400

Form

solid

Potency

>5000 mg/kg LD₅₀, oral (Rat)
>3000 mg/kg LD₅₀, skin (Rabbit)

Color

white

Kinematic Viscosity

4.2 cSt(100 °C)

Transition Temp

flash point >100 °C

Density

0.9 g/cm³at 20 °C

Application(S)

diagnostic assay manufacturing
hematology
histology

Storage Temp.

15-25°C

Related Categories

Hematology Stains

Tissue Diagnostics Universal Reagents

General Description

Paraffin pastilles - solidification point about 56-58 °C for histology, are a highly pure ready-to-use paraffin product. Paraffins are the materials generally used to embed the specimens for histological applications. In order to achieve uniformous ribbon-sectioning quality, defined hardness and homogeneity of the processed material is necessary. This can be guarranteed through high-quality raw materials and defined melting points. The melting point of Paraffin is 56-58°C. It is registered as IVD and CE certified product and can be used for clinical diagnostics. For more details, please see instructions for use (IFU).

Application

• Clinical application of targeted tumour sequencing tests for detecting ERBB2 amplification and optimizing anti-HER2 therapy in gastric cancer.: This study demonstrates the use of paraffin-embedded tissue samples in targeted tumor sequencing to identify patients suitable for anti-HER2 therapy, highlighting paraffin′s utility in preserving sample integrity for genetic analysis (Ichikawa et al., 2024).


• Novel FFPE proteomics method suggests prolactin induced protein as hormone induced cytoskeleton remodeling spatial biomarker.: Describes a novel proteomics method using formalin-fixed paraffin-embedded (FFPE) samples to identify biomarkers for hormone-induced changes in cellular structures, advancing tissue-specific molecular diagnostics (Faktor et al., 2024).


• TSWIFT, a novel method for iterative staining of embedded and mounted human brain sections.: Introduces TSWIFT, a new technique for the iterative staining of paraffin-embedded human brain sections, providing enhanced imaging capabilities for neurological research (Porter et al., 2024).


• [Optimal melanin removal methods for HE staining, immunohistochemistry and molecular detection].: Investigates various methods for melanin removal in HE staining processes involving paraffin-embedded samples, crucial for accurate histopathological and immunohistochemical analyses (Zhang et al., 2024).


• Novel Histopathological Findings of Micro Bone Fragments and Epithelial Response in the Oral Mucosa in Bisphosphonate-Related Osteonecrosis of the Jaw.: This case report utilizes paraffin-embedded sections to uncover novel histopathological insights into osteonecrosis, demonstrating paraffin′s role in detailed structural analysis in pathological conditions (Koizumi et al., 2024).

Storage Class

11 - Combustible Solids

Wgk_Germany

nwg

Flash_Point_F

Not applicable

Flash_Point_C

Not applicable