Sigma-Aldrich Fmoc-D-Ser(Po(Obzl)Oh)-Oh

Quality Level

200

Product Line

Novabiochem^®

Form

solid

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Functional Group

Fmoc

Storage Temp.

15-25°C

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

An excellent building block for the preparation of D-phosphoserine-containing peptides by Fmoc SPPS. This derivative can be introduced using standard activation methods, such as PyBOP^®and TBTU. The monoprotected phosphoserine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Peptides containing Post-Translational ModificationsNovabiochem^®

Linkage

Replaces: 04-13-1078

Analysis Note

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in DMF): +9.5 - +12.5 °
Purity (TLC(CMA1)): ≥ 97 %
Assay (HPLC, area%): ≥ 95.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 2.0 %

To see the solvent systems used for TLC of Novabiochem^®products please click here.Novabiochem is a registered trademark of Merck KGaA, Darmstadt, GermanyPyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany