Sigma-Aldrich 4-Sulfamylbutyryl Am Resin

Quality Level

200

Product Line

Novabiochem^®

Form

beads

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Functional Group

sulfonamide

Storage Temp.

2-30°C

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

Safety-catch resin for synthesis of C-terminally modified peptides by Fmoc SPPS. Linker is activated to cleavage by nucleophiles by methylation using TMS-diazomethane.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Application

• The First Solid-phase Synthesis and Structural Studies on Phakellistatin 15:This study describes the use of 4-sulfamylbutyryl AM resin for the solid-phase synthesis of Phakellistatin 15, highlighting the resin′s role in peptide synthesis and its effectiveness in loading Fmoc-Leu-OH. (Shaheen et Al., 2016).

Linkage

Replaces: 01-64-0152

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.60 - 1.20 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 200 -400 mesh.Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany