Sigma-Aldrich Ibx Polystyrene Novabioche

Quality Level

200

Product Line

Novabiochem^®

Form

beads

Reaction Suitability

reaction type: solution phase peptide synthesis
reactivity: alcohol reactive

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Storage Temp.

2-8°C

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

This polymer-bound version of IBX cleanly converts primary and secondary alcohols to the corresponding aldehydes and ketones ^[1,2] . It is particularly useful for the synthesis of peptide aldehydes as it oxidises peptide alcohols efficiently and spent resin can be simply removed by filtration.

Literature references

g. Sorg, et Al. (2001)Angew. Chem. Int. Ed.,40, 4395.
g. Sorg, et Al. (2005)J. Pept. Sci.,11, 147.

Application

• 2-Iodoxybenzoic Acid: An Oxidant for Functional Group Transformations:This study discusses the use of IBX for various organic transformations, including the oxidation of silyl enol ethers and the preparation of polystyrene supported periodinane reagent. (Nair, 2020).

Linkage

Replaces: 01-64-0445

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined by elemental analysis of iodine): 0.90 - 1.50 mmol/g
Oxidation of Cinnamyl alcohol to Cinnamaldehyde (2 eq. IBX PS): ≥ 90 %
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene - 1% DVB) 200 -400 mesh.Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany