Sigma-Aldrich Pal-Novasyn Tg Resin Novab

Quality Level

200

Product Line

NovaSyn^®TG
Novabiochem^®

Form

beads

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Functional Group

amine

Storage Temp.

2-8°C

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

PAL-NovaSyn TG resin consists of Barany′s aminomethyl-dimethoxyphenoxyvaleric acid linker attached to NovaSyn TG resin. The amino group of this linker can be easily acylated under standard coupling conditions. Following peptide assembly, treatment with 95% TFA containing scavengers releases the desired peptide amide. Studies have shown the acid sensitivity of this linker to be around twice that of the Rink amide linker . There is some evidence to suggest that PAL resins give greater yields in microwave assisted synthesis.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Analysis Note

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer metrix is copoly (styrene - 1% DVB), 100 - 200 mesh.NOVASYN is a registered trademark of Merck KGaA, Darmstadt, GermanyNovabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany