Sigma-Aldrich Medbz Novasyn(R)Tgr Resin

Quality Level

200

Product Line

NovaSyn^®TG
Novabiochem^®

Form

solid

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Functional Group

amine

Storage Temp.

2-8°C

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

MeDbz NovaSyn TGR resin is a second generation Dbz resin that overcomes the problem of branched peptide formation of the original and provides a robust approach to the synthesis of peptide thioesters by Fmoc SPPS. This product is used exactly in the same manner as standard Dbz resins except that special conditions are not required for loading of the first amino acid. Peptide chain extension is performed on the 4-anilino group, followed by formation of an imidazolidinone (MeNbz) with p-nitrophenyl chloroformate, and cleavage from the resin with TFA. The peptide-MeNbz is used directly in chemical ligation reactions to generate in situ the desired peptide thioester.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis ResinsNOVASYN is a registered trademark of Merck KGaA, Darmstadt, GermanyNovabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany