Sigma-Aldrich H-Cys(Trt)-2-Cltrt Resin N

Quality Level

200

Product Line

Novabiochem^®

Form

beads

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Storage Temp.

2-8°C

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

Pre-loaded resin for synthesis of protected peptide acids containing a C-terminal cysteine amino-acid residue by Fmoc SPPS. Cleavage of the protected peptide is effected by treatment with 1% TFA in DCM or 20% TFE in C649 DCM. The use of this resin enables the synthesis of peptides containing C-terminal cysteine without risk of racemization or β-piperidinylalanine formation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Linkage

Replaces: 04-12-2811

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.30 - 0.90 mmol/g
Swelling Volume (in DMF): lot specific result
Identity (of the substitution): passes test
The polymer matrix is copoly (styrene-1 % DVB), 200 - 400 mesh.Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany