Sigma-Aldrich Superspher(R) 100 RP-18 En

Product Name

Superspher^®100 RP-18 endcapped LiChroCART^®125-4, suitable for HPLC

Material

stainless steel column

Quality Level

100

Agency

suitable for USP L1

Product Line

Superspher^®

Feature

endcapped

Parameter

250 bar pressure
60 °C max. temp.

Technique(S)

HPLC: suitable
mass spectrometry (MS): suitable (Low - Medium)

Column L × I.D.

12.5 cm × 4 mm

Matrix

fully porous particle

Related Categories

HPLC Columns

General Description

HPLC cartridgeSuperspher^®RP-18 endcapped is a reliable and versatile traditionally produced spherical silica gel carriers with C-18 endcapped reversed phase properties. They are well suited for the separation of neutral, acidic and weak basic compounds. This high performance silica carrier with a particle size of 4µm yields an excellent pressure/separation performance ratio.This sorbent is packed into a LiChroCART 125-4 HPLC cartridge. The connection to the HPLC system is being accomplished by use of the manu-CART NT cartrige holder (1.51486).

Application

• Chemometric approach for estimation of ropinirole hydrochloride:This study presents a chemometric approach for the development and validation of an HPLC method for estimating ropinirole hydrochloride using LiChrospher 100 RP-18 columns. The method shows robustness and efficiency for pharmaceutical analysis (Fatima et Al., 2019).


• Simultaneous quantification of Parkinson′s disease medications:An HPLC method using LiChrospher 100 RP-18 was validated for simultaneous quantification of levodopa, carbidopa, benserazide, and entacapone in complex matrices, proving its capability in pharmaceutical formulations (Wollmer & Klein, 2017).


• Stability of THCA and (9)-THC in herbal cannabis:This research employed LiChrospher 100 RP-18 columns to determine the stability of THCA and Δ(9)-THC in herbal cannabis under different storage temperatures, important for forensic and pharmaceutical sciences (Taschwer & Schmid, 2015).


• Stability indicating method for cilazapril:Researchers developed a rapid and simple stability-indicating HPLC method for cilazapril, using LiChrospher 100 RP-18, to assess drug stability in pharmaceuticals, compared to spectrophotometric methods, highlighting its precision and reliability (Paszun et Al., 2012).

Analysis Note

Pressure: ≤ 80 bar
Theoretical Plates (N/M) (Anthracene): ≥ 100000
Symmetry (Anthracene): 0.8 - 1.4
Capacity factor (Anthracene): 3.5 - 5.5LICHROCART is a registered trademark of Merck KGaA, Darmstadt, GermanySuperspher is a registered trademark of Merck KGaA, Darmstadt, Germany