Sigma-Aldrich 5,7-Dichlorokynurenic Acid

Assay

≥99% (HPLC)

Quality Level

100

Form

solid

Potency

79 nM K_i

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
protect from light

Color

white

Solubility

water: 10 mM
1 M NaOH: 100 mM

Storage Temp.

2-8°C

Inchi

1S/C10H5Cl2NO3.Na/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14;/h1-3H,(H,13,14)(H,15,16);/q;+1/p-1

General Description

A very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (K_i= 79 nM vs. [3H]-glycine).

Biochem/Physiol Actions

Primary Target
NMDA receptors

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Baron, B., et al. 1991.Eur. J. Pharmacol. 206,149.
Baron, B., et al. 1990.Mol. Pharmacol. 38,554.
Mugnaini, M., et al. 1998.J. Recept. Signal Transduct. Res. 18,91.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany