Sigma-Aldrich (S)-(-)-Raclopride - Cas 8

Assay

≥98% (HPLC)

Quality Level

100

Form

solid

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
protect from light

Color

off-white

Solubility

DMSO: 100 mm
ethanol: 25 mm

Storage Temp.

2-8°C

Inchi

1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m1/s1

Inchi Key

WAOQONBSWFLFPE-SECBINFHSA-N

General Description

D₂-like dopamine receptor antagonist targeting D₂R (pKi =8.0), D₃R (pKi = 7.9), and 5-HT1A R (pKi=5.2). Used to explore D₂like receptor mediated effects in neuropathic pain, and in antagonism studies of DA receptors during heroin usage and cocaine. D₂Receptor selectivity in various preps shows IC₅₀values around 32 nM.

Biochem/Physiol Actions

Reversible: yes

Warning

Toxicity: Standard Handling (A)

Other Notes

Dang, Y. H. et Al. 2010.Neurosci. 169,1872.

Platt, D. M. et Al. 2010.J. Pharmacol. Exp. Ther. 332,985.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany