Sigma-Aldrich Tlr8 Agonist, Cpd14b - Cal

Assay

≥98% (HPLC)

Quality Level

100

Form

powder

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
protect from light

Color

white

Solubility

DMSO: 100 mg/mL

Storage Temp.

2-8°C

General Description

A pentyl-quinoline derived compound that acts as a pure, potent agonist of Toll-like receptor 8 agonist (TLR8, EC₅₀= 200 nM in a human TLR8-specifc reporter gene assay). Does not affect TLR2, 3, 4, 5, 7, 9, 10, Nod1 and Nod2, and is devoid of any TLR7 activity. Shown to induce activities of several cytokines and chemokines, including IL-1a, IL-1b, IL-6, IL-8, IL-10, IL12, IL-18, IFN-g, CCL20, RANTES, GRO, GM-CSF, and Eotaxin (~ 10 mg/mL).A pentyl-quinoline derived compound that acts as a pure, potent agonist of Toll-like receptor 8 agonist (TLR8, EC₅₀= 200 nM in a human TLR8-specifc reporter gene assay). Does not affect TLR2, 3, 4, 5, 7, 9, 10, Nod1 and Nod2, and is devoid of any TLR7 activity. Shown to induce activities of several cytokines and chemokines, including IL-1a, IL-1b, IL-6, IL-8, IL-10, IL12, IL-18, IFN-g, CCL20, RANTES, GRO, GM-CSF, and Eotaxin (~ 10 mg/mL).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/Physiol Actions

Cell permeable: yesPrimary Target
TLR8Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Kokatla, H. P., et Al. 2014,ChemMedChem 9,719.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany