Sigma-Aldrich Trxr Inhibitor, D9 - Calbi

Assay

≥98% (HPLC)

Quality Level

100

Form

solid

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
protect from light

Color

white

Solubility

DMSO: 100 mg/mL

Storage Temp.

−20°C

General Description

A cell permeable, highly stable phosphinyl gold (I) acetylide complex that acts as a highly potent inhibitor of thioredoxin reductase (TrxR; EC₅₀= 2.8 nM). Acts by blocking the redox-active selenenylsulfide motif of TrxR in an irreversible manner. Displays high selectivity over glutathione reductase (EC₅₀>1000 nM). Selectively reduces the viability and proliferation of MCF-7 and HT-29 cancer cells (IC₅₀= 30 and 100 nM, respectively) without affecting normal cells. Suppresses the growth of MCF-7 xenografts in BALB/c nude mice (5 mg/kg; i.v.,given on alternate days for 15 days).A cell permeable, highly stable phosphinyl gold (I) acetylide complex that acts as a highly potent inhibitor of thioredoxin reductase (TrxR; EC₅₀= 2.8 nM). Acts by blocking the redox-active selenenylsulfide motif of TrxR in an irreversible manner. Displays high selectivity over glutathione reductase (EC₅₀>1000 nM). Selectively reduces the viability and proliferation of MCF-7 and HT-29 cancer cells (IC₅₀= 30 and 100 nM, respectively) without affecting normal cells. Suppresses the growth of MCF-7 xenografts in BALB/c nude mice (5 mg/kg; i.v.,given on alternate days for 15 days).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.TrxR Inhibitor, D9, is a cell permeable, highly stable phosphinyl gold (I) acetylide complex that acts as a highly potent inhibitor of thioredoxin reductase (TrxR; EC₅₀ = 2.8 nM).

Biochem/Physiol Actions

Cell permeable: yesPrimary Target
TrxRReversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Zhang, D., et al. 2014.J. Med. Chem. 57,8132.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany