Sigma-Aldrich Fmoc-Glu-Odmab Novabiochem

Quality Level

200

Product Line

Novabiochem^®

Assay

≥90% (TLC)
≥96.0% (HPLC)

Form

powder

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Functional Group

carboxylic acid

Storage Temp.

15-25°C

Inchi

1S/C40H44N2O8/c1-24(2)19-33(37-34(43)20-40(3,4)21-35(37)44)41-26-15-13-25(14-16-26)22-49-36(45)18-17-32(38(46)47)42-39(48)50-23-31-29-11-7-5-9-27(29)28-10-6-8-12-30(28)31/h5-16,24,31-32,41H,17-23H2,1-4H3,(H,42,48)(H,46,47)

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

Quasi-orthogonally-protected Glu derivative. The Dmab group can be removed selectively in the presence of tBu-based protecting groups by treatment with 2% hydrazine in DMF , making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS or for library synthesis. For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(ivDde) and Glu(ODmab) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

W. C. Chan, et Al. (1995)J. Chem. Soc., Chem. Commun., 2209.

Linkage

Replaces: 04-12-1174

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 90 %
Purity (TLC(0811)): ≥ 90 %
Assay (HPLC, area%): ≥ 96.0 % (a/a)

To see the solvent systems used for TLC of Novabiochem^®products please click here.Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany