Sigma-Aldrich Fmoc-Tyr(2-Cltrt)-Oh Novab

Quality Level

200

Product Line

Novabiochem^®

Assay

≥98% (TLC)
≥99.0% (HPLC)

Form

powder

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Functional Group

hydroxyl

Storage Temp.

2-8°C

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

The side-chain ClTrt group can be removed with 1% TFA/ 5% TIS in DCM, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support during Fmoc SPPS.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

K. Barlos, et Al. (1998)J. Peptide Res.,51, 194.

Linkage

Replaces: 04-12-1184

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 mL DMF): clearly soluble
Water (K. F.): ≤ 4.0 %

To see the solvent systems used for TLC of Novabiochem^®products please click here.Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany