Sigma-Aldrich Fmoc-Dpr(Boc-Aoa)-Oh Novab

Quality Level

200

Product Line

Novabiochem^®

Assay

≥95.0% (acidimetric)
≥96.0% (HPLC)
≥98% (TLC)

Form

powder

Reaction Suitability

reagent type: ligand

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Functional Group

Boc
Fmoc

Storage Temp.

2-30°C

Inchi

1S/C25H29N3O8/c1-25(2,3)36-24(33)28-35-14-21(29)26-12-20(22(30)31)27-23(32)34-13-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,26,29)(H,27,32)(H,28,33)(H,30,31)/t20-/m0/s1

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

An excellent derivative for the chemoselective ligation of unprotected peptides in aqueous media via oxime formation. This derivative introduces a hydroxylamine functionality which can couple with aldehyde groups present in another peptide unit.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

F. Wahl & M. Mutter (1996)Tetrahedron Lett.,37, 6861.

Linkage

Replaces: 04-12-1185

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA2)): ≥ 98 %
Assay (HPLC, area%): ≥ 96.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 95.0 %
Water (K. F.): ≤ 2.00 %

To see the solvent systems used for TLC of Novabiochem^®products please click here.Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany