Sigma-Aldrich Fmoc-Phe(Cf2po3)-Oh Novabi

Quality Level

200

Product Line

Novabiochem^®

Assay

≥90.0% (HPLC)

Form

powder

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Functional Group

Fmoc

Storage Temp.

2-8°C

Inchi

1S/C25H22F2NO7P/c26-25(27,36(32,33)34)16-11-9-15(10-12-16)13-22(23(29)30)28-24(31)35-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,28,31)(H,29,30)(H2,32,33,34)/t22-/m0/s1

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

Building block for the introduction by Fmoc SPPS of the hydrolytically stable phosphotyrosine analog phosphonodifluoromethylphenylalanine (F2Pmp) . The pKa of F2Pmp more closely resembles that of a phosphate group making it better analog than phosphonomethylphenylalanine.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS

Literature references

M. F. Gordeev, et Al. (1994)Tetrahedron Lett.,35, 7585.
T. R. Burke, Jr. (2006)Curr. Top. Med. Chem.,6, 1465.

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 90.0 % (a/a)
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany