Sigma-Aldrich Fmoc-Sdma(Boc)2-Ona Novabi

Quality Level

200

Product Line

Novabiochem^®

Assay

≥90.0% (HPLC)

Form

powder

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Functional Group

Boc
Fmoc

Storage Temp.

-10 to -25°C

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

A derivative for the introduction of symmetric dimethyl-arginine during Fmoc SPPS. Coupling can be carried out using any standard activation method. Removal of the Boc protecting groups occurs during the course of the TFA-mediated cleavage reaction. Ref contains methods and protocols for the synthesis of arrays of histone-related peptides containing methylated arginine and lysine-residues.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS

Literature references

S. Rothbart, et Al. (2012)Methods Enzymol.,512, 107.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 90.0 % (a/a)
Solubility (1 mmole in 2 mL DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^®products please click here.Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany