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Sigma-Aldrich (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
List Price
$322.35
Your Price
$322.35
Sigma-Aldrich (Benzotriazol-1-Yloxy)Tripyrrolidino- Phosphonium Pf6 - SIAL (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
SIAL-12805-25G-F
MFG.PART:
12805-25G-F
UNSPSC:
12352000
Manufacturer:
Sigma-Aldrich
grade
purum
Quality Level
200
assay
≥97.0% (TLC)
form
solid
reaction suitability
reaction type: Coupling Reactions
mp
~150 °C
154-156 °C (dec.) (lit.)
application(s)
peptide synthesis
storage temp.
2-8°C
SMILES string
F[P-](F)(F)(F)(F)F.C1CCN(C1)[P+](On2nnc3ccccc23)(N4CCCC4)N5CCCC5
InChI
1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
Related Categories
Amino Acids, Resins & Reagents for Peptide Synthesis
Phosphates
General description
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification.[1] It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.[2]
Application
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies:
- As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates.[3]
- Synthesis of structured pure triacylglycerol (TAG) regioisomers.[1]
- As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support.[4]
- Synthesis of herceptin- nanoparticles.[5]
Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product.
Legal Information
PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany
pictograms
GHS07,GHS09
signalword
Warning
hcodes
H302,H317,H410
pcodes
P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1
wgk_germany
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
| SKU | SIAL-12805-25G-F |
|---|---|
| Featured | No |
| Supplier Part Number | 12805-25G-F |
| UM | EA |
| UNSPSC | 12352000 |
| Manufacturer | Sigma-Aldrich |
| Temperature | 2-8C |
| Refrigerated-Frozen | Y |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 10.000000 |
| Lead Time | 9 |
| Hazardous | Y |
| CAS Number | 128625-52-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |