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Recombinant DNA expressed in yeast (S. cerevisiae).
Description
Catalogue Number
01-106
Brand Family
Upstate
Trade Name
Upstate
Description
FGF-2 / basic FGF Protein, Human recombinant
Product Information
Presentation
Liquid in PBS, pH 7.4, containing 0.5% BSA and 0.1% CHAPS.
Quality Level
MQ100
Applications
Application
The FGF-2 / basic FGF Protein, Human recombinant is available in a 25 µg format.
Key Applications
Cell Culture
Biological Information
Source
Recombinant DNA expressed in yeast (S. cerevisiae).
Entrez Gene Number
NM_002006.3
Entrez Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
Gene Symbol
FGF2
Prostatropin
BFGF
prostatropin
HBGF-2
FGFB
Purification Method
Heparin-Sepharose™ chromatography
UniProt Number
P09038
UniProt Summary
FUNCTION: SwissProt: P09038 # The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. SIZE: 155 amino acids; 17254 Da SUBUNIT: Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2. SIMILARITY: SwissProt: P09038 ## Belongs to the heparin-binding growth factors family. MISCELLANEOUS: This protein binds heparin more strongly than does aFGF.
Stem Cell Type
Human Embryonic Stem Cells
Neural Stem Cells
Epithelial Cells
Mesenchymal Stem Cells
Pancreatic Stem Cells
Induced Pluripotent Stem Cells
Product Usage Statements
Quality Assurance
Routinely evaluated by Biological Activity Assay. Cultures of fetal bovine heart endothelial (FBHE) cells grown for five days in RD medium containing FBS, heparin, and FGF-2 showed more cells than cultures of FBHE cells grown in same medium without FGF-2.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
