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Recombinant rat Ciliary Neurotrophic Factor expressed in E. coli
Entrez Gene Number
NM_000614.2
Entrez Gene Summary
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also co-transcribed with the upstream ZFP91 gene. Co-transcription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.
Gene Symbol
CNTF
HCNTF
Purification Method
Sterilized through a 0.2 micron membrane filter
UniProt Number
P26441
UniProt Summary
FUNCTION: SwissProt: P26441 # CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SIZE: 200 amino acids; 22931 Da SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. SIMILARITY: SwissProt: P26441 ## Belongs to the CNTF family.
Product Usage Statements
Quality Assurance
Routinely evaluated in a biological activity assay.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
