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Millipore Use Anti-Tal-1 Antibody, Clone Btl73 (Mouse Monoclonal Antibody) Validated In Wb, Ihc To Detect Tal-1 Also Known As Scl, T-Cell Acute Lymphocytic Leukemia 1, Tcl5, Tal-1, Stem Cell Protein. - Mill (Additional S&H or Hazmat Fees May Apply)
TAL-1, also known as SCL (stem cell leukemia), is a serine phosphoprotein and basic-helix-loop-helix transcription factor. TAL-1 is implicated in the genesis of hemopoietic malignancies and is a positive regulator of erythroid differentiation. A nonrandom, site-specific TAL-1 chromosomal translocation is commonly associated with oncogenic transformation in many T-cell acute lymphoblastic leukemias. TAL-1 binds to the LIM domain containing protein Rhombotin 2 (RBTN2), where it forms a complex with GATA1 or GATA 2 that is essential for erythropoiesis.
Product Information
Format
Affinity Purified
Control
Jurkat cell lysate
Presentation
Purified mouse monoclonal IgG1k in buffer containing PBS and 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Use Anti-TAL-1 Antibody, clone BTL73 (Mouse Monoclonal Antibody) validated in WB, IHC to detect TAL-1 also known as SCL, T-cell acute lymphocytic leukemia 1, TCL5, TAL-1, Stem cell protein.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Western Blot Analysis: 2 μg/mL of this lot detected a strong 44 kDa of PP42-TAL1 in Jurkat cell lysate, and also very faint PP24-TAL. Optimal working dilutions must be determined by the end user.
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Specificity
This antibody detects two predominant protein products of the SCL/TAL1 gene in T cell acute lymphoblastic leukemia (T-ALL): a full length PP42-TAL1 (42/44 kDa) and a truncated form PP24-TAL1 (24/26 kDa).
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_003180
Gene Symbol
TAL1
SCL
TCL5
Purification Method
Protein G Purified
UniProt Number
P17542
Molecular Weight
44 kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by western blot on Jurkat cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
