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0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%.
Quality Level
MQ100
Applications
Application
Anti-GADS Antibody is an antibody against GADS for use in IP & WB.
Key Applications
Immunoprecipitation
Western Blotting
Biological Information
Immunogen
KLH-conjugated, synthetic peptide corresponding to amino acids 174-188 of murine GADS (GEEIRPSVNRKLSDH)
Host
Rabbit
Specificity
GADS
Isotype
IgG
Species Reactivity
Human
Mouse
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_004810
Entrez Gene Summary
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.
Gene Symbol
GRAP2
GRB2L
GADS
GRBX
GrbX
GRBLG
GRAP-2
Mona
P38
GRPL
Grf40
GRID
Grf-40
OTTHUMP00000028837
Purification Method
Protein A chromatography
UniProt Number
O75791
UniProt Summary
FUNCTION: SwissProt: O75791 # Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. SIZE: 330 amino acids; 37909 Da SUBUNIT: Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. SIMILARITY: SwissProt: O75791 ## Belongs to the GRB2/sem-5/DRK family. & Contains 1 SH2 domain. & Contains 2 SH3 domains.
Molecular Weight
40kDa
Product Usage Statements
Quality Assurance
routinely evaluated by immunoblot on Jurkat RIPA cell lysate
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
