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Cyclic adenosine monophosphate or cAMP is an intracellular by-product of ATP by adenylene cyclase when g-protein Coupled Receptors (GPCR) bind various ligands on the cell surface. Cyclic AMP acts as a second messenger for signal transduction across the cell membrane and is a part of kinase activation. It regulates the effects of glucagon and adrenaline along with the movement of calcium ions through ion channels. Since it is affected directly by GPCR activation, cAMP is studied as a means to monitor GPCR in the discovery of therapeutic drugs.
Product Information
Format
Serum
Control
Rat hippocampus and cerebellum tissue
Presentation
Diluted serum presented as liquid in PBS containing no preservatives.
Quality Level
MQ100
Applications
Application
Anti-cAMP Antibody detects level of cAMP & has been published & validated for use in IH(P).
Key Applications
Immunohistochemistry (Paraffin)
Biological Information
Immunogen
2O-succinyl cyclic AMP conjugated to BSA
Host
Rabbit
Specificity
Specific for cAMP with no cross reaction to other nucleotides at concentrations to 1 mm. Reactive with cAMP fixed in tissues or acetylated cAMP. Not reactive with free, non-acetylated, cAMP in RIA or EIA assays.
Species Reactivity
Rat
Species Reactivity Note
Proven to react with rat. Expected to react with all species.
Antibody Type
Polyclonal Antibody
Purification Method
Unpurified rabbit serum
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in rat hippocampus and cerebellum tissue. Immunohistochemistry Analysis: 1:100 dilution of this lot detected cAMP in rat hippocampus and cerebellum tissue.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20°C in undiluted aliquots from date of shipment. Avoid repeated freeze/thaw cycles.
